Snowman, known as Jimmy before mankind was overwhelmed by a plague, is struggling to survive in a world where he may be the last human, and mourning the loss of his best friend, Crake, and the beautiful and elusive Oryx whom they both loved. In search of answers, Snowman embarks on a journey - with the help of the green-eyed Children of Crake - through the lush wilderness that was so recently a great city, until powerful corporations took mankind on an uncontrolled genetic engineering ride.