This resource is a synthesis of current research and an introduction to the theory and practice of differentiated instruction within an Alberta context. The resource if organized into three parts. Part 1 offers general information and strategies for differentiating instruction. Part 2 provides ideas for differentiating learning and teaching for specific student groups, including English as a second language learners, students with disabilities and students who are gifted. Part 3 offers practical, curriculum-specific ideas and strategies for differentiating learning and teaching within four core subject areas.