JR and his friends are on their way to Prague with his human, George, and George's Russian girlfriend, Nadya, where they plan to take in the sights and meet Nadya's brother, a circus performer. But something is amiss at the circus-- the animals are unhappy. Not only that, but a fancy new circus is coming to town, threatening to put everyone out of a job. It's up to JR and the embassy dogs to save the show, with the help of some unlikely accomplices.